Buserelin
Buserelin is a sample topic from the davis s drug guide.
Buserelin. It is available as a nasal spray or under the skin injection. Each time you collect your prescription for buserelin check to make sure the brand name is suprefact. To view other topics please sign in or purchase a subscription. This is because there is another brand of buserelin nasal spray available which is not suitable for you.
Anesthesia central is an all in one web and mobile solution for treating patients before during and after surgery. Belongs to the class of gonadotropin releasing hormone analogues. Suprefact eases symptoms associated with the condition. Find null b1168000 msds related peer reviewed papers technical documents similar products more at sigma aldrich.
Used in endocrine therapy. Buserelin is a gonadotropin releasing hormone agonist gnrh agonist. Interactions of buserelin with gnrh causes immediate release of follicle stimulating hormone fsh and luteinizing hormone lh by gonadotrophes. Suprefact buserelin acetate marketed by sanofi is a medication for the treatment of endometriosis.
Prevention of the transient adverse effects of a gonadotropin releasing hormone analogue buserelin in metastatic prostatic carcinoma by administration of an antiandrogen nilutamide. This collection of drug procedures and test information is derived from davis s drug mgh clinical. Buserelin is a potent lhrh gnrh agonist. In experiments 4 and 5 buserelin was as effective as hcg in inducing ovulation between 24 and 48 h after initiation of treatment.
Buserelin treatment induced a rise in lh concentration during the. Please send me a quote. Buserelin european pharmacopoeia ep reference standard. Buserelin stimulates the pituitary gland s gonadotrophin releasing hormone receptor gnrhr.
Definition of buserelin a synthetic analog of gonadotropin releasing hormone gnrh. When administered as a single dose buserelin stimulates pituitary gonadotrophin release whereas multiple doses result in dose dependent depletion of gonadotrophins. This information is independently developed by cims based on buserelin from various references and is provided for your reference only. Extended exposure to buserelin induces down regulation of gnrh receptors leading to suppression of lh and fhs from the pituitary.
Buserelin binds to and activates pituitary gonadotropin releasing hormone gnrh receptors. Buserelin desensitizes the gnrh receptor reducing the amount of lh and testosterone. Structure properties spectra suppliers and links for. Buserelin brand name suprefact is a hormone treatment for men with prostate cancer who have not had surgery to remove the testicles.
Buserelin is a synthetic analogue of gnrh which is an agonist at pituitary gnrh receptors. After a transient increase continuous administration of buserelin results in downregulation of lh and fsh levels followed by a suppression of ovarian and testicular steroid biosynthesis.